The physical microbe : an introduction to noise, control, and communication in the prokaryotic cell /

• Κύριος συγγραφέας: Hagen, Stephen J. (συγγραφέας.)
• Μορφή: Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: San Rafael [Καλιφόρνια] : Morgan & Claypool Publishers, c2017.
• Σειρά: IOP concise physics.
• Θέματα: Προκαρυώτες; Βιοφυσική; Μικροβιολογία

Physical biology is a fusion of biology and physics. This book narrows down the scope of physical biology by focusing on the microbial cell; exploring the physical phenomena of noise, feedback, and variability that arise in the cellular information-processing circuits used by bacteria. It looks at t...

Πίνακας περιεχομένων:

• Preface : why the physical microbe?
• 1. Introduction
• 1.1. Diversity
• 1.2. Size
• 1.3. Energy
• 1.4. Food
• 1.5. Diffusion versus size
• 2. Growth
• 2.1. Exponential growth
• 2.2. Stationary phase
• 2.3. Lag phase and decline
• 2.4. Balanced growth
• 2.5. Partitioning of resources
• 2.6. Individual cells in balanced growth
• 3. Gene regulatory networks
• 3.1. Transcription and translation
• 3.2. Representation of networks and pathways
• 3.3. Gene regulation basics
• 3.4. Deterministic models for gene regulation
• 4. Stochastic gene expression
• 4.1. Variability at low copy number
• 4.2. Modeling stochastic expression
• 4.3. Bursts of gene expression
• 4.4. Protein distributions with both transcription and translation
• 4.5. Intrinsic and extrinsic noise
• 4.6. Noise reduction and stability through feedback
• 5. Phenotypic switching
• 5.1. Two types of persisters
• 5.2. Toxin-antitoxin systems and HipBA
• 5.3. Bet-hedging by phenotypic switching
• 6. Communication
• 6.1. Chemical communication
• 6.2. Pheromone triggered transitions of nonlinear systems
• 6.3. Electrical communication
• 7. Bacillus subtilis competence and sporulation : the final exam
• 7.1. Competence decision by noisy autofeedback
• 7.2. Phosphorelay sensor for sporulation
• 7.3. A mutually repressing circuit inhibits competence
• 7.4. Input from intercellular communication.