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03182nam a22005655i 4500 |
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20151030131028.0 |
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|a 9780306468384
|9 978-0-306-46838-4
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|a 10.1007/b112581
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|a Taurine 4
|h [electronic resource] :
|b Taurine and Excitable Tissues /
|c edited by Laura Della Corte, Ryan J. Huxtable, Giampietro Sgaragli, Keith F. Tipton.
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|a Boston, MA :
|b Springer US,
|c 2002.
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|a XXIV, 652 p.
|b online resource.
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 483
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|a Keynote Presentation -- Appreciations -- Plenary Presentations -- Basic Aspects and Peripheral Actions of Taurine -- Metabolic and Nutritional Aspects -- Taurine in the CNS -- Taurine Analogues and Metals: Health Care Aspects -- Taurine and Vision -- Taurine and Cell Homeostatic Mechanisms -- Clinical Aspects.
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|a Mitochondria from mammalian tissues possess an elaborate system for 2+ 2+ transporting Ca across their inner membrane which consists of Ca import, 2+ via the Ca uniporter, in response to the mitochondrial membrane 2+ + potential ?? and of Ca release by an antiport system in exchange for H + 9,23 or Na (see Fig. l) . Because the uniporter is dependent upon the external 2+ 2+ 2+ 2+ Ca concentration ([Ca ]), mitochondria accumulate Ca until the [Ca ] o o 2+ decreases to the level at which the uniporter activity balances the Ca efflux. 2+ The [Ca ] at which the uniporter and efflux activities are equal is defined o the “setpoint” andcorresponds to values between 0.3-3µM. 2+ Figure 1. The Ca transport system of the inner membrane of mammalian mitochondria. U, + 2+ + + uniporter. I, Na -independent efflux mechanism or Ca /2H exchanger. D, Na -dependent 2+ + efflux mechanism or Ca /2Na exchanger. PTP, permeability transition pore. FP, 11 flavoprotein. ?? membrane potential. ? pH gradient. Adapted from .
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|a Life sciences.
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|a Pharmacology.
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|a Nutrition.
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|a Neurology.
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|a Biochemistry.
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|a Life Sciences.
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|a Biochemistry, general.
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|a Pharmacology/Toxicology.
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|a Nutrition.
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|a Neurology.
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|a Corte, Laura Della.
|e editor.
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|a Huxtable, Ryan J.
|e editor.
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|a Sgaragli, Giampietro.
|e editor.
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|a Tipton, Keith F.
|e editor.
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9780306464478
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 483
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|u http://dx.doi.org/10.1007/b112581
|z Full Text via HEAL-Link
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|a Biomedical and Life Sciences (Springer-11642)
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