Advanced Methods of Pharmacokinetic and Pharmacodynamic Systems Analysis Volume 3

• Corporate Author: SpringerLink (Online service)
• Other Authors: D’Argenio, David Z. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2004.
• Series: The International Series in Engineering and Computer Science, 765
• Subjects: Medicine.; Pharmacology.; Computers.; Statistics.; Biomedical engineering.; Biomedicine.; Pharmacology/Toxicology.; Statistics for Life Sciences, Medicine, Health Sciences.; The Computing Profession.; Biomedical Engineering.

Advanced Methods of Pharmacokinetic and Pharmocodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering. Both basic and clinical scientists will benefit from this work. This book contains chapters by leading researchers in pharmacok...

Table of Contents:

• Mechanism-Based PK/PD
• Physiological Modeling of the Small Intestine in Drug Absorption
• Intracellular Metabolism of Lamivudine
• Mechanism-Based Pharmacodynamic Modeling for Prediction of Exposure Response
• Mechanism-Based PK/PD Modeling of Digoxin: Role of Receptor Heterogeneity and Postrecepotor Events
• Pharmacodynamics and Pharmacogenomics of Corticosteroids: Microarray Studies
• Bayesian Inference in Physiologically-based Pharmacokinetic Modeling: Application to Aniticancer Drug Development
• Pharmacometrics
• Monte Carlo Parametric Expectation Maximization (MC-PEM) Method for Analyzing Population Pharmacokinetic/Pharmacodynamic Data
• Applications of Markov Chain Monte Carlo Methods to Inverse Problems in PK/PD
• Regenerative Markov Chain Monte Carlo Methods for Pharmacokinetic/Pharmacodynamic Estimation
• Vizstruct: A Multidimensional Visualization Algorithm for Gene Expression
• Pharmacotherapy
• Modeling and Simulation of Effects of Adherence, Pharmacokinetic, and Pharmacodynamic Characteristics in Development of Resistance to HIV Regimens in Treatment-Naive Patients
• Mechanistic PK/PD Modeling of Antiretroviral Therapies in AIDS Clinical Trials
• Dose Individualization for High-dose anti-cancer Chemotherapy
• Toward Model-Based Chemotherapy Treatment Design
• Control of Uncertain Pharmacodynamic Systems.