Alzheimer’s Disease Cellular and Molecular Aspects of Amyloid β /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Harris, J. Robin (Επιμελητής έκδοσης), Fahrenholz, Falk (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Boston, MA : Springer US, 2005.
• Σειρά: Subcellular Biochemistry, 38
• Θέματα: Life sciences.; Neurosciences.; Biochemistry.; Life Sciences.; Biochemistry, general.

This book contains a survey of present-day research into the biomedical fundamentals of Alzheimer’s disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that...

Πίνακας περιεχομένων:

• The Contribution of Microscopy to the Study of Alzheimer’s Disease, Amyloid Plaques and A? Fibrillogenesis
• Transgenic Mouse Models for APP Processing and Alzheimer’s Disease: Early and Late Defects
• Oxidative stress in Alzheimer’s Disease: Implications for Prevention and Therapy
• ?-Secretase, APP and A? in Alzheimer’s Disease
• The Non-Amyloidogenic Pathway: Structure and Function of ?-Secretases
• Amyloid ? Degradation: A Challenging Task for Brain Peptidases
• The Protective Role of Vitamin E in Vascular Amyloid ?-Mediated Damage
• Amyloid Accumulation and Pathogensis of Alzheimer’s Disease: Significance of Monomeric, Oligomeric and Fibrillar A?
• Cholesterol and Amyloid ? Fibrillogenesis
• Alzheimer’s ?-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding
• The Aluminium-Amyloid Cascade Hypothesis and Alzheimer’s Disease
• Amyloid-? Metal Interaction and Metal Chelation
• The Interaction of Amyloid-? with ApoE
• Clusterin and Alzheimer’s Disease
• Acetylcholinesterase Interaction with Alzheimer Amyloid ?
• Membrane Disordering Effects of ?-Amyloid Peptides
• The Role of Alzheimer A? Peptides in Ion Transport Across Cell Membranes
• Amyloid Inhibitors and ?-Sheet Breakers
• Cholesterol and Alzheimer’s Disease: Statins, Cholesterol Depletion in APP Processing and A? Generation
• Phosphorylated Amyloid-?: the Toxic Intermediate in Alzheimer’s Disease Neurodegeneration.