Neurodegeneration and Prion Disease

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Brown, David R. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Boston, MA : Springer US, 2005.
• Θέματα: Medicine.; Molecular biology.; Neurosciences.; Neurology.; Veterinary medicine.; Biochemistry.; Biomathematics.; Biomedicine.; Physiological, Cellular and Medical Topics.; Biochemistry, general.; Veterinary Medicine.; Molecular Medicine.

This volume provides an in-depth overview from world experts on prion disease. These fatal diseases include Creutzfeldt-Jakob disease, chronic wasting disease in deer, scrapie of sheep, bovine spongiform encephalopathy (mad cow’s disease) of cattle and related diseases. Understanding what causes neu...

Πίνακας περιεχομένων:

• Neuropathology of Transmissible Spongiform Encephalopathies (Prion Diseases)
• Central Pathogenesis of Prion Diseases
• Hereditary Prion Protein Amyloidoses
• Mouse Behavioural Studies and What They Can Teach Us about Prion Diseases
• Electrophysiological Approaches to the Study of Prion Diseases
• Prion Protein, Prion Protein-Like Protein, and Neurodegeneration
• Oxidative Stress and Mitochondrial Dysfunction in Neurodegeneration of Transmissible Spongiform Encephalopathies (TSEs)
• Mechanisms of Prion Toxicity and Their Relationship to Prion Infectivity
• A Stone Guest on the Brain: Death as a Prion
• Molecular Mechanisms Mediating Neuronal Cell Death in Experimental Models of Prion Diseases, in vitro
• Processing and Mis-Processing of the Prion Protein: Insights into the Pathogenesis of Familial Prion Disorders
• Signaling Pathways Controling Prion Neurotoxicity: Role of Endoplasmic Reticulum Stress-Mediated Apoptosis
• Cell Culture Models to Unravel Prion Protein Function and Aberrancies in TSE
• Insights into the Cellular Trafficking of Prion Proteins
• The Molecular Basis of Prion Protein-Mediated Neuronal Damage
• Conclusion: Intervention, the Final Frontier.