Proteomics and Protein-Protein Interactions Biology, Chemistry, Bioinformatics, and Drug Design /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Waksman, Gabriel (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2005.
• Series: Protein Reviews ; 3
• Subjects: Medicine.; Human genetics.; Human physiology.; Health informatics.; Biochemistry.; Proteomics.; Bioinformatics.; Biomedicine.; Human Physiology.; Health Informatics.; Human Genetics.; Biochemistry, general.

Gabriel Waksman Institute of Structural Molecular Biology, Birkbeck and University College London, Malet Street, London WC1E 7HX, United Kingdom Address for correspondence: Professor Gabriel Waksman Institute of Structural Molecular Biology Birkbeck and University College London Malet Street London...

Table of Contents:

• Introduction: Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, and Drug Design
• Yeast Two-Hybrid Protein-Protein Interaction Networks
• The Use of Mass Spectrometry in Studying Protein-Protein Interaction
• Molecular Recognition in the Immune System
• Computational Methods for Predicting Protein-Protein Interactions
• Protein-Protein Docking Methods
• Thermochemistry of Binary and Ternary Protein Interactions Measured by Titration Calorimetry: Complex Formation of CD4, HIV gp120, and Anti-gp120
• Protein-Protein Recognition in Phosphotyrosine-Mediated Intracellular Signaling
• Competitive Binding of Proline-Rich Sequences by SH3, WW, and Other Functionally Related Protein Domains
• The Structure and Molecular Interactions of the Bromodomain
• SMART Drug Design: Novel Phosphopeptide and ATP Mimetic-Based Small Molecule Inhibitors of the Oncogenic Protein Kinase pp60src (Src)
• Disrupting Protein-Protein Interaction: Therapeutic Tools Against Brain Damage
• A Thermodynamic Guide to Affinity Optimization of Drug Candidates.