The p53 Tumor Suppressor Pathway and Cancer

• Corporate Author: SpringerLink (Online service)
• Other Authors: Zambetti, Gerard P. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2005.
• Series: Protein Reviews ; 2
• Subjects: Medicine.; Cancer research.; Human genetics.; Oncology.; Medical biochemistry.; Biochemistry.; Cell biology.; Biomedicine.; Cancer Research.; Biochemistry, general.; Cell Biology.; Medical Biochemistry.; Human Genetics.

The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a tran...

Table of Contents:

• The p53 Network
• The Three-Dimensional Structure of p53
• Transcriptional Activation by p53: Mechanisms and Targeted Genes
• Transcriptional Repression by the p53 Tumor Suppressor Protein
• Posttranslational Modifications of p53: Upstream Signaling Pathways
• p53 in Human Cancer — Somatic and Inherited Mutations and Mutation-independent Mechanisms
• MDM2 and MDMX Regulators of p53 Activity
• p53 Family Members: p63 and p73
• The Oncogenic Activity of p53 Mutants
• Therapeutic Strategies Based on Pharmacological Modulation of p53 Pathway.