Principles of Protein X-Ray Crystallography

X-ray crystallography has long been a vital method for studying the structure of proteins and other macromolecules. As the importance of proteins continues to grow, in fields from biochemistry and biophysics to pharmaceutical development and biotechnology, many researchers have found that a knowledg...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριος συγγραφέας: Drenth, Jan (Συγγραφέας)
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: New York, NY : Springer New York, 2007.
Θέματα:
Διαθέσιμο Online:Full Text via HEAL-Link
LEADER 04067nam a22005175i 4500
001 978-0-387-33746-3
003 DE-He213
005 20151204154946.0
007 cr nn 008mamaa
008 100301s2007 xxu| s |||| 0|eng d
020 |a 9780387337463  |9 978-0-387-33746-3 
024 7 |a 10.1007/0-387-33746-6  |2 doi 
040 |d GrThAP 
050 4 |a QH345 
050 4 |a QD415-436 
072 7 |a PSB  |2 bicssc 
072 7 |a SCI007000  |2 bisacsh 
082 0 4 |a 572  |2 23 
100 1 |a Drenth, Jan.  |e author. 
245 1 0 |a Principles of Protein X-Ray Crystallography  |h [electronic resource] /  |c by Jan Drenth. 
264 1 |a New York, NY :  |b Springer New York,  |c 2007. 
300 |a XIV, 332 p.  |b online resource. 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b c  |2 rdamedia 
338 |a online resource  |b cr  |2 rdacarrier 
347 |a text file  |b PDF  |2 rda 
505 0 |a Crystallizing a Protein -- X-ray Sources and Detectors -- Crystals -- Theory of X-ray Diffraction by a Crystal -- Average Reflection Intensity and Distribution of Structure Factor Data -- Special Forms of the Structure Factor -- The Solution of the Phase Problem by the Isomorphous Replacement Method -- Phase Improvement -- Anomalous Scattering in the Determination of the Protein Phase Angles and the Absolute Configuration -- Molecular Replacement -- Direct Methods -- Laue Diffraction -- Refinement of the Model Structure -- The Combination of Phase Information -- Checking for Gross Errors and Estimating the Accuracy of the Structural Model -- Practical Protein Crystallization. 
520 |a X-ray crystallography has long been a vital method for studying the structure of proteins and other macromolecules. As the importance of proteins continues to grow, in fields from biochemistry and biophysics to pharmaceutical development and biotechnology, many researchers have found that a knowledge of X-ray diffraction is an indispensable tool. In this new edition of his essential work, Dr. Jan Drenth, recognized internationally for his numerous contributions to crystallographic research, has provided an up-to-date and technically rigorous introduction to the subject. Principles of Protein X-ray Crystallography provides the theoretical background necessary to understand how the structure of proteins is determined at atomic resolution. It is intended to serve as an introduction for graduate students, postdoctoral researchers, and established scientists who want to use protein crystallography in their own endeavors, or need to understand the subject in order to critically evaluate the literature. New additions to the book include a section on twinning, an additional chapter on crystal growth and a discussion of single-wavelength anomalous dispersion (SAD). Reviews: "The new edition... will bring important and significant, and timely, coverage of twinning and of SAD phasing." – Professor John Helliwell, Department of Chemistry, University of Manchester "a complete and up to date... single source of theory." – Duncan McRee, President, ActiveSight About the Authors: Dr. Jan Drenth is a professor emeritus at the Laboratory of Biophysical Chemistry at the University of Groningen, The Netherlands. Contributing author Dr. Jeroen R. Mesters Ph.D. is a Senior Research Assistant at the Institute of Biochemistry, University of Luebeck, Germany. 
650 0 |a Life sciences. 
650 0 |a Analytical chemistry. 
650 0 |a Biochemistry. 
650 0 |a Biophysics. 
650 0 |a Biological physics. 
650 0 |a Environmental law. 
650 0 |a Environmental policy. 
650 1 4 |a Life Sciences. 
650 2 4 |a Biochemistry, general. 
650 2 4 |a Analytical Chemistry. 
650 2 4 |a Biophysics and Biological Physics. 
650 2 4 |a Environmental Law/Policy/Ecojustice. 
710 2 |a SpringerLink (Online service) 
773 0 |t Springer eBooks 
776 0 8 |i Printed edition:  |z 9780387333342 
856 4 0 |u http://dx.doi.org/10.1007/0-387-33746-6  |z Full Text via HEAL-Link 
912 |a ZDB-2-SBL 
950 |a Biomedical and Life Sciences (Springer-11642)