Hedgehog-Gli Signaling in Human Disease

• Main Author: Ruiz i Altaba, Ariel (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2006.
• Series: Molecular Biology Intelligence Unit
• Subjects: Medicine.; Cancer research.; Human genetics.; Developmental biology.; Biomedicine.; Cancer Research.; Developmental Biology.; Human Genetics.

Hedgehog-GLI Signaling in Human Disease represents the first compilation of up-to-date reviews by top-level scientists in this important field of research. The chapters cover a wide spectrum of related interests, from the molecular bases of morphogen function, to human genetics to cancer research. T...

Table of Contents:

• How the Hedgehog Outfoxed the Crab
• The Patched Receptor
• Making a Morphogenetic Gradient
• Spatial and Temporal Regulation of Hair Follicle Progenitors by Hedgehog Signaling
• Mode of PTCH1/Ptch1-Associated Tumor Formation
• Basal Cell Carcinomas, Hedgehog Signaling, and the Ptch1+/- Mouse
• GLI Genes and Their Targets in Epidermal Development and Disease
• Splitting Hairs
• Shh Expression in Pulmonary Injury and Disease
• Human Correlates of GLI3 Function
• From Oligodactyly to Polydactyly
• The Genetics of Indian Hedgehog
• Sonic Hedgehog Signaling in Craniofacial Development
• Important Role of Shh Controlling Gli3 Functions during the Dorsal-Ventral Patterning of the Telencephalon
• Regulation of Early Events in Cell Cycle Progression by Hedgehog Signaling in CNS Development and Tumorigenesis
• Modulating the Hedgehog Pathway in Diseases
• Hedgehog Signaling in Endodermally Derived Tumors.