Alzheimer’s Disease Advances in Genetics, Molecular and Cellular Biology /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Sisodia, Sangram S. (Editor), Tanzi, Rudolph E. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2007.
• Subjects: Medicine.; Neurosciences.; Pharmacology.; Geriatrics.; Neurology.; Neurobiology.; Biomedicine.; Pharmacology/Toxicology.; Geriatrics/Gerontology.; Medicine/Public Health, general.

Alzheimer’s Disease: Advances in Genetics, Cellular and Molecular Biology provides exciting, comprehensive and up-to-date summaries of the most important recent advances in the genetic, molecular, biochemical, and cell biological studies of AD. The studies and advances described in this volume will...

Table of Contents:

• The Genetics of Alzheimer’s Disease
• APP Biology, Processing and Function
• The Biology of the Presenilin Complexes
• ?-secretase: Physiological Role and Target Validation
• Cognitive Impairment in Transgenic A? and Tau Models of Alzheimer’s Disease
• Cholesterol and ?-Amyloid
• A? Structure and Aggregation
• Signaling Mechanisms that Mediate A? Induced Neuronal Dysfunction
• Beta Amyloid and Excitatory Synapses
• A? Degradation
• Role of A ? Transport and Clearance in the Pathogenesis and Treatment of Alzheimer’s Disease
• Tau Gene Mutations in FTDP-17 Syndromes
• Animal Models of Tauopathy
• Tau and Axonal Transport
• Growth Factors in Alzheimer’s Disease.