Sigma Receptors Chemistry, Cell Biology and Clinical Implications /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Su, Tsung-Ping (Editor), Matsumoto, Rae R. (Editor), Bowen, Wayne D. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2007.
• Subjects: Medicine.; Neurosciences.; Pharmacology.; Chemistry.; Psychiatry.; Biochemistry.; Cell biology.; Biomedicine.; Chemistry/Food Science, general.; Pharmacology/Toxicology.; Biochemistry, general.; Cell Biology.

Sigma receptors are promising drug development targets for a host of neurological, psychiatric, oncological, immunological, cardiovascular, ophthalmological, and gastrointestinal disorders. They are structurally unique proteins that are distinct from classical G protein-coupled receptors, ionotropic...

Table of Contents:

• ? Receptors: Historical Perspective and Background
• Medicinal Chemistry: New Chemical Classes and Subtype-Selective Ligands
• Irreversible ? Compounds
• Pharmacophore Models for ?1 Receptor Binding
• Cloning of ?1 Receptor and Structural Analysis of Its Gene and Promoter Region
• Site-Directed Mutagenesis
• ? Receptor Modulation of Ion Channels
• Subcellular Localization and Interacellular Dynamics of ?1 Receptors
• Intracellular Signaling and Synaptic Plasticity
• Modulation of Classical Neurotransmitter Systems by ? Receptors
• ?2 Receptors: Regulation of Cell Growth and Implications for Cancer Diagnosis and Therapeutics
• Cognitive Effects of ? Receptor Ligands
• ? Receptors and Scizophrenia
• Potential Role of ? Ligands and Neurosteroids in Major Depression
• ? Receptors and Drug Abuse
• ?1 Receptors and the Modulation of Opiate Analgesics
• ? Receptors in the Immune System: Implications for Potential Therapeutic Intervention - An Overview
• ? Receptors and Gastrointestinal Function.