DNA Repair and Human Disease

• Main Author: Balajee, Adayabalam S. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2006.
• Series: Medical Intelligence Unit
• Subjects: Medicine.; Human genetics.; Medical microbiology.; Cell biology.; Biomedicine.; Human Genetics.; Medical Microbiology.; Cell Biology.

DNA Repair and Human Disease highlights the molecular complexities of a few well-known human hereditary disorders that arise due to perturbations in the fidelity of diverse DNA repair machineries.

Table of Contents:

• Human Premature Aging Disorders and Dysfunction of DNA Repair
• DNA Repair Aspects for RecQ Helicase Disorders
• Trichothiodystrophy
• Roles of the BRCA1 and BRCA2 Breast Cancer Susceptibility Proteins in DNA Repair
• Radiosensitivity of Cells Derived from Down Syndrome Patients
• The Fanconi Anemia/BRCA Pathway
• Is Ataxia Telangiectasia a Result of Impaired Coordination between DNA Repair and Cell Cycle Checkpoint Regulators?
• Mechanisms of DNA Damage and Repair in Alzheimer Disease
• Orchestration of Telomeres and DNA Repair Factors in Mammalian Cells
• Defective Solar Protection in Xeroderma Pigmentosum and Cockayne Syndrome Patients.