Optimizing the “Drug-Like” Properties of Leads in Drug Discovery

• Corporate Author: SpringerLink (Online service)
• Other Authors: Borchardt, Ronald T. (Editor), Kerns, Edward H. (Editor), Hageman, Michael J. (Editor), Thakker, Dhiren R. (Editor), Stevens, James L. (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2006.
• Series: Biotechnology: Pharmaceutical Aspects ; IV
• Subjects: Medicine.; Pharmacology.; Biomedicine.; Pharmacology/Toxicology.

Drug discovery and development is a very complex, costly, and ti- consuming process. Because of the uncertainties associated with predicting the pharmacological effects and the toxicity characteristics of new chemical entities in man, their clinical development is quite prone to failure. In recent y...