Optimizing the “Drug-Like” Properties of Leads in Drug Discovery

Optimizing the “Drug-Like” Properties of Leads in Drug Discovery

Drug discovery and development is a very complex, costly, and ti- consuming process. Because of the uncertainties associated with predicting the pharmacological effects and the toxicity characteristics of new chemical entities in man, their clinical development is quite prone to failure. In recent y...

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Λεπτομέρειες βιβλιογραφικής εγγραφής
Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
Άλλοι συγγραφείς: Borchardt, Ronald T. (Επιμελητής έκδοσης), Kerns, Edward H. (Επιμελητής έκδοσης), Hageman, Michael J. (Επιμελητής έκδοσης), Thakker, Dhiren R. (Επιμελητής έκδοσης), Stevens, James L. (Επιμελητής έκδοσης)
Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
Γλώσσα:English
Έκδοση: New York, NY : Springer New York, 2006.
Σειρά:Biotechnology: Pharmaceutical Aspects ; IV
Θέματα:
Medicine.
Pharmacology.
Biomedicine.
Pharmacology/Toxicology.
Διαθέσιμο Online:Full Text via HEAL-Link
Πίνακας περιεχομένων:
  • Strategic Use of Preclinical Pharmacokinetic Studies and In Vitro Models in Optimizing ADME Properties of Lead Compounds
  • Role of Mechanistic Transport Studies in Lead Optimization
  • Metabolic Activation-Role in Toxicity and Idiosyncratic Reactions
  • Case History — Use of ADME Studies for Optimization of Drug Candidates
  • Solubility, Solubilization and Dissolution in Drug Delivery During Lead Optimization
  • Lipid-based Systems, Drug Exposure and Lead Optimization
  • Biopharmaceutics Modeling and the Role of Dose and Formulation on Oral Exposure
  • Application of Physicochemical Data to Support Lead Optimization by Discovery Teams
  • Computational Models Supporting Lead Optimization in Drug Discovery
  • Prodrug Strategies for Improving Drug-Like Properties
  • The Application of Multivariate Data Analysis to Compound Property Optimization
  • Case History: Toxicology Biomarker Development Using Toxicogenomics
  • Predicting Idiosyncratic Drug Reactions
  • Elementary Predictive Toxicology for Advanced Applications
  • The Application of PK/PD Modeling and Simulations During Lead Optimization
  • Early Preclinical Evaluation of Brain Exposure in Support of Hit Identification and Lead Optimization
  • Optimizing Biomarker Development for Clinical Studies at the Lead Optimization Stage of Drug Development
  • The Relevance of Transporters in Determining Drug Disposition.

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