Statistical Monitoring of Clinical Trials A Unified Approach /

• Main Authors: Proschan, Michael A. (Author), Lan, K. K. Gordan (Author), Wittes, Janet Turk (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2006.
• Series: Statistics for Biology and Health,
• Subjects: Statistics.; Statistics for Life Sciences, Medicine, Health Sciences.

The approach taken in this book is, to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal, this book shows t...

Table of Contents:

• A General Framework
• Power: Conditional, Unconditional, and Predictive
• Historical Monitoring Boundaries
• Spending Functions
• Practical Survival Monitoring
• Inference Following a Group-Sequential Trial
• Options When Brownian Motion Does Not Hold
• Monitoring for Safety
• Bayesian Monitoring
• Adaptive Sample Size Methods
• Topics Not Covered
• Appendix I: The Logrank and Related Tests
• Appendix II: Group-Sequential Software.