Cardiac Mechanotransduction

• Main Authors: Weckström, Matti (Author), Tavi, Pasi (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2007.
• Subjects: Medicine.; Human physiology.; Cardiology.; Cell biology.; Biomedicine.; Human Physiology.; Cell Biology.

For about hundred years the investigation of heart physiology has had one central guiding principle, the "law" of Frank and Starling. This connects the return of blood into the heart and the blood pressure with cardiac con­ traction force. The "law" does it in a way that enables...

Table of Contents:

• The Mechanosensory Heart
• Origin of Mechanotransduction
• The Role of the Sarcomere and Cytoskeleton in Cardiac Mechanotransduction
• Mechanoelectric Transduction/Feedback: Physiology and Pathophysiology
• Mechanotransduction in Cardiac Remodeling and Heart Failure
• Second Messenger Systems Involved in Heart Mechanotransduction
• The Role of Adrenoceptors in Mechanotransduction
• Intracellular Signaling Through Protein Kinases in Cardiac Mechanotransduction
• Mechanotransduction of the Endocrine Heart.