Multiple Testing Procedures with Applications to Genomics

• Main Authors: Dudoit, Sandrine (Author), Laan, Mark J. van der (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2008.
• Series: Springer Series in Statistics,
• Subjects: Life sciences.; Bioinformatics.; Statistics.; Life Sciences.; Statistical Theory and Methods.; Statistics for Life Sciences, Medicine, Health Sciences.

This book establishes the theoretical foundations of a general methodology for multiple hypothesis testing and discusses its software implementation in R and SAS. The methods are applied to a range of testing problems in biomedical and genomic research, including the identification of differentially...

Table of Contents:

• Multiple Hypothesis Testing
• Test Statistics Null Distribution
• Overview of Multiple Testing Procedures
• Single-Step Multiple Testing Procedures for Controlling General Type I Error Rates, ?(Fvn)
• Step-Down Multiple Testing Procedures for Controlling the Family-Wise Error Rate
• Augmentation Multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates
• Resampling-Based Empirical Bayes multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates
• Simulation Studies: Assessment of Test Statistics Null Distributions
• Identification of Differentially Expressed and Co-Expressed Genes in High-Throughput Gene Expression Experiments
• Multiple Tests of Association with Biological Annotation Metadata
• HIV-1 Sequence Variation and Viral Replication Capacity
• Genetic Mapping of Complex Human Traits Using Single Nucleotide Polymorphisms: The ObeLinks Project
• Software Implementation.