The Statistics of Gene Mapping

• Main Authors: Siegmund, David (Author), Yakir, Benjamin (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2007.
• Series: Statistics for Biology and Health,
• Subjects: Medicine.; Human genetics.; Computer simulation.; Bioinformatics.; Animal genetics.; Biomathematics.; Statistics.; Biomedicine.; Human Genetics.; Statistics for Life Sciences, Medicine, Health Sciences.; Simulation and Modeling.; Animal Genetics and Genomics.; Genetics and Population Dynamics.

Gene mapping is used in experimental genetics to improve the hardiness or productivity of animals or plants of agricultural value, to explore basic mechanisms of inheritance, or to study animal models of human inheritance. In human populations it is used as a first step to identify genes associated...

Table of Contents:

• Background and Preparations
• Background in Statistics
• to Experimental Genetics
• Fundamentals of Genetics: Inbreeding, Recombination, Random Mating, and Identity by Descent
• Experimental Genetics
• Testing for Linkage with a Single Marker
• Whole Genome Scans: The Significance Level
• Statistical Power and Confidence Regions
• Missing Data and Interval Mapping
• Advanced Topics
• Human Genetics
• Mapping Qualitative Traits in Humans Using Affected Sib Pairs
• Admixture Mapping
• Mapping Complex and Quantitative Traits with Data from Human Pedigrees
• Association Studies
• Inferring Haplotypes from Genotypes and Testing Association.