Prodrugs Challenges and Rewards Part 1 /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Stella, Valentino J. (Editor), Borchardt, Ronald T. (Editor), Hageman, Michael J. (Editor), Oliyai, Reza (Editor), Maag, Hans (Editor), Tilley, Jefferson W. (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2007.
• Series: Biotechnology: Pharmaceutical Aspects ; V
• Subjects: Medicine.; Pharmacology.; Biomedicine.; Pharmacology/Toxicology.

Prodrugs are substances administered in an inactive form that is then metabolized in the body in vivo into the active compound. The rationale behind administering prodrugs is to optimize absorption, distribution, metabolism, and excretion of these drugs. Since first described in the 1950s, prodrugs...