Modulation of Protein Stability in Cancer Therapy

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Rubin, Eric (Επιμελητής έκδοσης), Sakamoto, Kathleen (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer US, 2009.
• Θέματα: Medicine.; Cancer research.; Human genetics.; Immunology.; Medical microbiology.; Biochemistry.; Biomedicine.; Cancer Research.; Medical Microbiology.; Human Genetics.; Biochemistry, general.
• Φυσική περιγραφή: X, 165 p. 35 illus. online resource.
• ISBN: 9780387691473

This book contains chapters written by experts in the field of the ubiquitin proteasome system and cancer. The authors have summarized current information on ubiquitin ligases and proteasomes as potential targets for cancer therapy. Topics covered in the book include an overview of ubiquitin ligases, deubiquitinating enzymes, and the proteasome. Specific diseases resulting from deregulated ubiquitin ligases, such as Von-Hippel-Lindau disease and Fanconi anemia are also discussed. Finally, novel approaches and drugs to target proteins involved in sumoylation, ubiquitination, and degradation are described.