Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Augustijns, Patrick (Επιμελητής έκδοσης), Brewster, Marcus E. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York, 2007.
• Σειρά: Biotechnology: Pharmaceutical Aspects ; VI
• Θέματα: Medicine.; Pharmacology.; Programming languages (Electronic computers).; Biomedicine.; Pharmacology/Toxicology.; Programming Languages, Compilers, Interpreters.

Solvent systems are integral to drug development and pharmaceutical technology. This single topic encompasses numerous allied subjects running the gamut from recrystallization solvents to biorelevant media. The goal of this contribution to the AAPS Biotechnology: Pharmaceutical Aspects series is to...

Πίνακας περιεχομένων:

• Principles of Solubility
• Ionic Equilibria and the pH Dependence of Solubility
• Solvent Systems for Crystallization and Polymorph Selection
• Solubility Issues in Early Discovery and HTS
• Practical Aspects of Solubility Determination in Pharmaceutical Preformulation
• Biorelevant Dissolution Media
• Selection of Solvent Systems for Membrane-, Cell- and Tissue-Based Permeability Assessment
• The Use of Solubilizing Excipients and Approaches to Generate Toxicology Vehicles for Contemporary Drug Pipelines
• Solubilizing Vehicles for Oral Formulation Development
• Solubilizing Systems for Parenteral Formulation Development—Small Molecules
• Aqueous Solubilizing Systems for Parenteral Formulation Development—Proteins
• Non-Aqueous Systems for Formulation Development—Proteins
• Pharmaceutical Solvents as Vehicles for Topical Dosage Forms
• Pharmaceutical Solvents for Pulmonary Drug Delivery.