Genetically Engineered Mice for Cancer Research design, analysis, pathways, validation and pre-clinical testing /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Green, Jeffrey E. (Επιμελητής έκδοσης), Ried, Thomas (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York, 2012.
• Θέματα: Medicine.; Cancer research.; Human genetics.; Laboratory medicine.; Medical microbiology.; Parasitology.; Biochemistry.; Biomedicine.; Cancer Research.; Human Genetics.; Laboratory Medicine.; Medical Microbiology.; Animal Biochemistry.

Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors.  This book provides an overview of the design considerations and techn...

Πίνακας περιεχομένων:

• Foreword
• Preface
• Overview of Designing Genetically-Engineered Mouse Models
• The Use of Cre-loxP Technology and Inducible Systems to Generate Mouse Models of Cancer
• Using Recombineering Technology To Create Genetically Engineered Mouse Models
• Insertional Mutagenesis for Generating Mouse Models of Cancer
• The RCAS/TVA Somatic Gene Transfer Method In Modeling Human Cancer
• Target-selected ENU Mutagenesis to Develop Cancer Models in the Rat
• The Tumor Pathology of Genetically Engineered Mice: Genomic Pathology
• Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer
• Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping (SKY), FISH, and immunocytochemistry
• Expression Profiling of Mouse Models of Human Cancer: model categorization and guidance for preclinical testing
• Imaging mouse models of human cancer
• Identifying Mammary Epithelial Stem and Progenitor Cells
• Differentiation Programs in Development and Cancer
• Roles of p53 and PRB Tumor Suppressor Networks in Human Cancer: Insight from Studies in the Engineered Mouse
• Mouse Models for Colorectal Cancer
• Src family tyrosine kinases: Implications for mammary tumor progression
• Maspin and Suppression of Tumor Metastasis
• Epigenetic Mouse Models
• Modeling Transforming Growth Factor-ß Signaling in Cancer
• Modeling Stromal-Epithelial Interactions.-  Utilizing Mouse Models of Human Cancer for Assessing Immune-Modulation of Cancer Development.-  Transplanted Tumor Models For Preclinical Drug Testing And The Potential Benefit Of Genetically Engineered Mouse Models
• The Development and Use of Genetically Tractable Pre-Clinical Mouse Models
• Animal Models for Breast Cancer Prevention Resarch
• Oncogene Addiction: Mouse Models and Clinical Relevance for Molecularly Targeted Therapies
• Mouse Models in Preclinical Drug Development- Applications to CNS Models
• Mouse Models of Human Cancer: Role in Pre-clinical Testing and Personalized Medicine
• Mighty, But How Useful? The Emerging Role of Genetically Engineered Mice in Cancer Drug Discovery and Development
• Index.  .