TNF Receptor Associated Factors (TRAFs)

• Corporate Author: SpringerLink (Online service)
• Other Authors: Wu, Hao (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2007.
• Series: Advances in Experimental Medicine and Biology, 597
• Subjects: Life sciences.; Computer security.; Cell biology.; Developmental biology.; Life Sciences.; Cell Biology.; Developmental Biology.; Systems and Data Security.

It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embry...

Table of Contents:

• Phylogeny of the TRAF/MATH Domain
• TRAF1 and Its Biological Functions
• Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5
• TRAF3 and Its Biological Function
• TRAF4, the Unique Family Member
• Characteristics and Biological Functions of TRAF6
• Ubiquitination and TRAF signaling
• Structural Revelations of TRAF2 Function in TNF Receptor Signaling Pathway
• Protein-Protein Interactions in TRAF3
• Molecular Basis for the Unique Specificity of TRAF6
• TRAF Proteins in CD40 Signaling
• TRAFs in RANK Signaling
• The LT?R Signaling Pathway
• LMP1 TRAFficking Activates Growth and Survival pathways
• Targeting TRAFs for Therapeutic Intervention.