Mechanisms of Insulin Action Medical Intelligence Unit /

• Main Authors: Saltiel, Alan R. (Author), Pessin, Jeffrey E. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2007.
• Subjects: Medicine.; Cardiology.; Diabetes.; Endocrinology.; Cell biology.; Medicine & Public Health.; Cell Biology.

More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. In addition, between 17 and 40 million people have insulin resistance, impaired glucose tolerance, or the cluster of abnormalities referred to variably as the metaboli...

Table of Contents:

• Insulin and IGF-I Receptor Structure and Binding Mechanism
• Subcellular Compartmentalization of Insulin Signaling Processes and GLUT4 Trafficking Events
• Regulation of Insulin Action and Insulin Secretion by SNARE-Mediated Vesicle Exocytosis
• Control of Protein Synthesis by Insulin
• Hepatic Regulation of Fuel Metabolism
• Insulin Action Gene Regulation
• Insulin Action in the Islet ?-Cell
• Central Regulation of Insulin Sensitivity
• Transgenic Models of Impaired Insulin Signaling
• Insulin Resistance.