Mucosal Immune Defense: Immunoglobulin A

• Corporate Author: SpringerLink (Online service)
• Other Authors: Kaetzel, Charlotte Slayton (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2007.
• Subjects: Medicine.; Immunology.; Pharmacology.; Virology.; Allergy.; Infectious diseases.; Microbiology.; Biomedicine.; Infectious Diseases.; Pharmacology/Toxicology.; Allergology.

Antibodies of the IgA class form the front line of immune defense at mucosal surfaces lining the gastrointestinal, respiratory and genital tracts. These IgA antibodies promote peaceful co-existence with beneficial microorganisms, such as gut bacteria that assist in digestion and nutrient production,...

Table of Contents:

• The Structure of IgA
• IgA Plasma Cell Development
• Epithelial Transport of IgA by the Polymeric Immunoglobulin Receptor
• Fc Receptors for IgA
• Regulation of the Mucosal IgA System
• Biological Functions of IgA
• Protection of Mucosal Epithelia by IgA: Intracellular Neutralization and Excretion of Antigens
• Novel Functions for Mucosal SIgA
• IgA and Antigen Sampling
• IgA and Intestinal Homeostasis
• IgA and Respiratory Immunity
• IgA and Reproductive Tract Immunity
• IgA-Associated Diseases
• Mucosal SIgA Enhancement: Development of Safe and Effective Mucosal Adjuvants and Mucosal Antigen Delivery Vehicles
• Recombinant IgA Antibodies.