Biopharmaceutics Applications in Drug Development

• Corporate Author: SpringerLink (Online service)
• Other Authors: Krishna, Rajesh (Editor), Yu, Lawrence (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2008.
• Subjects: Medicine.; Pharmacology.; Biochemistry.; Biomedicine.; Pharmacology/Toxicology.; Biochemistry, general.

In the last two decades, the discipline of biopharmaceutics has undergone considerable advances, particularly with regard to bioavailability and bioequivalence as they relate to product quality and regulatory standards of approval. Textbooks in the field have not been able to keep up with the growth...

Table of Contents:

• to Biopharmaceutics and its Role in Drug Development
• Molecular and Physicochemical Properties Impacting OralAbsorptionofDrugs
• Dissolution Testing
• Drug Absorption Principles
• Evaluation of Permeability and P-glycoprotein Interactions: Industry Outlook
• Excipients as Absorption Enhancers
• IntestinalTransporters in Drug Absorption
• Bioavailability and Bioequivalence
• A Biopharmaceutical Classification System Approach to Dissolution: Mechanisms and Strategies
• Food Effects on Drug Bioavailability: Implications for New and Generic Drug Development
• In Vitro–In Vivo Correlation on Parenteral Dosage Forms
• In Vitro–In Vivo Correlation in Dosage Form Development: Case Studies.