Functional Nucleic Acids for Analytical Applications

• Corporate Author: SpringerLink (Online service)
• Other Authors: Yingfu, Li (Editor), Yi, Lu (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2009.
• Series: Integrated Analytical Systems
• Subjects: Chemistry.; Analytical chemistry.; Biotechnology.; Inorganic chemistry.; Organic chemistry.; Materials science.; Nanotechnology.; Analytical Chemistry.; Inorganic Chemistry.; Organic Chemistry.; Materials Science, general.

Both DNA and RNA can serve purposes beyond simple genetic storage and transfer – for example, they can also be employed as enzymes (for catalysis) and receptors (for ligand binding). Increasingly, researchers are making interesting use of these molecules, now collectively called functional nucleic...

Table of Contents:

• Overview of Functional Nucleic Acids and Their Analytical Applications
• Introductory Remarks
• Natural Functional Nucleic Acids: Ribozymes and Riboswitches
• Artificial Functional Nucleic Acids: Aptamers, Ribozymes, and Deoxyribozymes Identified by In Vitro Selection
• Functional Nucleic Acid Sensors Based on Different Transduction Principles
• Fluorescent Aptamer Sensors
• Fluorescent Ribozyme and Deoxyribozyme Sensors
• Colorimetric and Fluorescent Biosensors Based on Directed Assembly of Nanomaterials with Functional DNA
• Electrochemical Approaches to Aptamer-Based Sensing
• Amplified DNA Biosensors
• Other Emerging Analytical Applications
• Aptamers in Affinity Separations:Capillary Electrophoresis
• Aptamers in Affinity Separations: Stationary Separation
• Aptamer Microarrays
• The Use of Functional Nucleic Acids in Solid-Phase Fluorimetric Assays
• Functional Nucleic Acid Sensors as Screening Tools
• Nucleic Acids for Computation
• DNAzymes in DNA Nanomachines and DNA Analysis.