Drug Absorption Studies In Situ, In Vitro and In Silico Models /
In the last 15 years, a great number of cell- or tissue-based in vitro models have been introduced into the biopharmaceutics arena. These models mimic the different biological barriers that a drug has to overcome to finally reach its target organ/cell/receptor. These in vitro models have been found...
| Συγγραφή απο Οργανισμό/Αρχή: | |
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| Άλλοι συγγραφείς: | , |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
Boston, MA :
Springer US,
2008.
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| Σειρά: | Biotechnology: Pharmaceutical Aspects ;
VII |
| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Perfused Organ Level/In Situ Techniques
- Models for Skin Absorption and Skin Toxicity Testing
- Models of the Small Intestine
- Drug Absorption from the Colon In Situ
- In Vivo and In Vitro Models for Assessing Drug Absorption Across the Buccal Mucosa
- In Situ and Ex Vivo Nasal Models for Preclinical Drug Development Studies
- The Isolated Perfused Lung for Drug Absorption Studies
- Cellular Level—In Vitro Models of Epithelial and Endothelial Barriers
- In Vitro Models for Investigations of Buccal Drug Permeation and Metabolism
- In Vitro Screening Models to Assess Intestinal Drug Absorption and Metabolism
- In Vitro Cellular Models for Nasal Drug Absorption Studies
- In Vitro Models of the Tracheo-Bronchial Epithelium
- In Vitro Models of the Alveolar Epithelial Barrier
- Cell Culture Models of the Corneal Epithelium and Reconstructed Cornea Equivalents for In Vitro Drug Absorption Studies
- The Conjunctival Barrier in Ocular Drug Delivery
- Inner Blood—Retinal Barrier: Transport Biology and Methodology
- Regulation of Paracellular Permeability in Low-Resistance Human Vaginal-Cervical Epithelia
- In Vitro Models and Multidrug Resistance Mechanisms of the Placental Barrier
- In Vitro Models to Study Blood-Brain Barrier Function
- High-Throughput Screening Using Caco-2 Cell and PAMPA Systems
- Instrumented In Vitro Approaches to Assess Epithelial Permeability of Drugs from Pharmaceutical Formulations
- Bioinformatics—In Silico Tools to Predict Drug Absorption
- Modeling Transdermal Absorption
- Physiologically Based in Silico Models for the Prediction of Oral Drug Absorption
- In Silico Modeling for Blood—Brain Barrier Permeability Predictions
- Molecular/Sub-Cellular Level—Mechanistic Tools
- Impact of Drug Transport Proteins
- Cloning and Functional Heterologous Expression of Transporters
- The Pharmacology of Caveolae
- Immortalization Strategies for Epithelial Cells in Primary Culture
- Binding-Uptake Studies and Cellular Targeting
- Regulatory Considerations
- Drug Permeability Studies in Regulatory Biowaiver Applications.
