Current Trends in Monoclonal Antibody Development and Manufacturing

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Shire, Steven J. (Επιμελητής έκδοσης), Gombotz, Wayne (Επιμελητής έκδοσης), Bechtold-Peters, Karoline (Επιμελητής έκδοσης), Andya, James (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York : Imprint: Springer, 2010.
• Σειρά: Biotechnology: Pharmaceutical Aspects ; XI
• Θέματα: Medicine.; Neurosciences.; Pharmacology.; Biomedicine.; Pharmacology/Toxicology.

Monoclonal antibodies represent one of the fastest growing areas of new drug development within the pharmaceutical industry. Several blockbuster products have been approved over the past several years including Rituxan, Remicade, Avastin, Humira, and Herceptin. In addition, over 300 new drugs are cu...

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• Addressing Changes Associated with Technology Transfer: A Case Study
• Concepts for Disposables in Biopharmaceutical Manufacture
• Formulation and Delivery
• Formulation and Delivery Issues for Monoclonal Antibody Therapeutics
• Challenges in the Development of High Protein Concentration Formulations
• Protein Immobilization by Crystallization and Precipitation: An Alternative to Lyophilization
• Analytics and Specification Setting for MABS
• Characterizing High Affinity Antigen/Antibody Complexes by Kinetic and Equilibrium Based Methods
• Analytical Characterization of Monoclonal Antibodies: Linking Structure to Function
• Analysis of Irreversible Aggregation, Reversible Self-association and Fragmentation of Monoclonal Antibodies by Analytical Ultracentrifugation
• Biophysical Signatures of Monoclonal Antibodies
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• Impact of Fc Glycosylation on Monoclonal Antibody Effector Functions and Degradation by Proteases
• Immunogenicity Assessment of Antibody Therapeutics
• Armed Antibodies and New Classes of Antibodies
• Production of Monoclonal Antibodies in E. coli
• Recent Advancements in the Use of Antibody Drug Conjugates for Cancer Therapy
• Antibody Radiolabeling.