Mitochondria and Cancer

• Corporate Author: SpringerLink (Online service)
• Other Authors: Costello, Leslie (Editor), Singh, Keshav (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2009.
• Subjects: Medicine.; Cancer research.; Laboratory medicine.; Medical microbiology.; Molecular biology.; Cell biology.; Biomedicine.; Cancer Research.; Medical Microbiology.; Molecular Medicine.; Cell Biology.; Biomedicine general.; Laboratory Medicine.

Nearly a century of scientific research has revealed that mitochondrial dysfunction is one of the most common and consistent phenotypes of cancer cells. A number of notable differences in the mitochondria of normal and cancer cells have been described. These include differences in mitochondrial meta...

Table of Contents:

• Mitochondria and Cancer
• Warburg and his Legacy
• The Lipogenic Switch in Cancer
• Citrate Metabolism in Prostate and Other Cancers
• Integration of Genetic, Proteomic, and Metabolic Approaches in Tumor Cell Metabolism
• Mitochondrial Respiration and Differentiation
• Integration of Energy Metabolism and Control of Apoptosis in Tumor Cells
• Energy Generating Pathways and the Tumor Suppressor p53
• Mitochondrial Tumor Suppressors
• Mitochondria in Hematology
• Mitochondria and Oncocytomas
• Mitochondria as Targets for Cancer Therapy
• Reversing the Warburg Effect: Metabolic Modulation as a Novel Cancer Therapy
• Mitochondrial Nanotechnology for Cancer Therapy.