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02763nam a22004455i 4500 |
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978-0-387-84847-1 |
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DE-He213 |
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20150519190926.0 |
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cr nn 008mamaa |
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100301s2008 xxu| s |||| 0|eng d |
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|a 9780387848471
|9 978-0-387-84847-1
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|a 10.1007/978-0-387-84847-1
|2 doi
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|a The Sarcomere and Skeletal Muscle Disease
|h [electronic resource] /
|c edited by Nigel G. Laing.
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|a New York, NY :
|b Springer New York,
|c 2008.
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|a XXII, 228 p.
|b online resource.
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|a text
|b txt
|2 rdacontent
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|a computer
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|a online resource
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|a text file
|b PDF
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 642
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|a The Sarcomere and Sarcomerogenesis -- Skeletal Muscle Alpha-Actin Diseases -- Nebulin—A Giant Chameleon -- Skeletal Muscle Disease Due to Mutations in Tropomyosin, Troponin and Cofilin -- Investigations into the Pathobiology of Thin-Filament Myopathies -- Mouse Models for Thin Filament Disease -- Thick Filament Diseases -- Acute Quadriplegic Myopathy: An Acquired “Myosinopathy” -- Third Filament Diseases -- The Z-Disk Diseases -- Intermediate Filament Diseases: Desminopathy -- Muscular Integrity—A Matter of Interlinking Distinct Structures via Plectin -- The Sarcomere and the Nucleus: Functional Links to Hypertrophy, Atrophy and Sarcopenia -- Other Model Organisms for Sarcomeric Muscle Diseases -- Therapeutic Approaches for the Sarcomeric Protein Diseases.
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|a Although best known for its role in heart disease, the sarcomere--the fundamental unit of muscle contraction--is also involved in skeletal muscle diseases. Chapters in The Sarcomere and Skeletal Muscle Disease provide an up-to-date review of diseases caused by mutated proteins in the different sub-compartments of the sarcomere, document the techniques currently being used to investigate the pathobiological bases of the diseases, which remain largely unknown, and discuss possible therapeutic options.
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|a Medicine.
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| 650 |
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|a Human physiology.
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| 650 |
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|a Biomedicine.
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| 650 |
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|a Biomedicine general.
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| 650 |
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4 |
|a Human Physiology.
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| 700 |
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|a Laing, Nigel G.
|e editor.
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| 710 |
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|a SpringerLink (Online service)
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|t Springer eBooks
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|i Printed edition:
|z 9780387848464
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| 830 |
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|a Advances in Experimental Medicine and Biology,
|x 0065-2598 ;
|v 642
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| 856 |
4 |
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|u http://dx.doi.org/10.1007/978-0-387-84847-1
|z Full Text via HEAL-Link
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| 912 |
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|a ZDB-2-SBL
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| 950 |
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|a Biomedical and Life Sciences (Springer-11642)
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