Viral Genome Replication

• Corporate Author: SpringerLink (Online service)
• Other Authors: Raney, Kevin D. (Editor), Gotte, Matthias (Editor), Cameron, Craig E. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Boston, MA : Springer US, 2009.
• Subjects: Medicine.; Human genetics.; Immunology.; Virology.; Biochemistry.; Cell biology.; Microbiology.; Biomedicine.; Cell Biology.; Biochemistry, general.; Human Genetics.

Currently, there is no single source that permits comparison of the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our particular system, missing out on the opportunity to de...

Table of Contents:

• Genome replication strategies
• Model of Picornavirus RNA Replication
• Coronavirus Genome Replication
• Flaviviruses
• Hepatitis C Virus Genome Replication
• Brome Mosaic Virus RNA Replication and Transcription
• Retroviruses
• Hepadnaviral Genomic Replication
• Rhabdoviruses
• Orthomyxovirus Genome Transcription and Replication
• Arenaviruses: Genome Replication Strategies
• Core-Associated Genome Replication Mechanisms of dsRNA Viruses
• Poxviruses
• Herpesvirus Genome Replication
• Host Factors Promoting Viral RNA Replication
• Host Factors that Restrict Retrovirus Replication
• Elements, factors and enzymes: Structure-function and mechanism
• T4 Phage Replisome
• Atomic Structure of the Herpes Simplex Virus 1 DNA Polymerase
• RNA Virus Polymerases
• Human Immunodeficiency Virus Reverse Transcriptase
• Viral Helicases
• Integrase: Structure, Function, and Mechanism
• Antivirals: Targets, mechanisms and resistance
• Viral DNA Polymerase Inhibitors
• Viral RNA Polymerase Inhibitors
• HIV-1 Reverse Transcriptase Inhibitors and Mechanisms of Resistance
• Lethal Mutagenesis
• Clinical Implications of Reverse Transcriptase Inhibitor Resistance.