Biophysics of DNA-Protein Interactions From Single Molecules to Biological Systems /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Williams, Mark C. (Editor), Maher, L. James (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York : Imprint: Springer, 2011.
• Series: Biological and Medical Physics, Biomedical Engineering,
• Subjects: Physics.; Molecular biology.; Biochemistry.; Proteins.; Cell biology.; Biophysics.; Biological physics.; Biomedical engineering.; Biophysics and Biological Physics.; Molecular Medicine.; Cell Biology.; Biomedical Engineering.; Biochemistry, general.; Protein Structure.

This book presents a concise overview of current research on the biophysics of DNA-protein interactions. A wide range of new and classical methods are presented by authors investigating physical mechanisms by which proteins interact with DNA. For example, several chapters address the mechanisms by w...

Table of Contents:

• Introduction
• Nonspecific DNA Binding: Searching DNA and Altering DNA Properties
• DNA Search Theory
• DNA Search, Hopping vs. Sliding
• SSB DNA Search
• HN-S Proteins or DNA Sliding Search
• Processivity Clamp
• DNA Bending Proteins
• Kinetics of DNA Binding and Bending by Proteins
• Modes of DNA Interaction by Architectural Proteins
• Complex Protein-DNA Interactions
• DNA Looping by Repressor Proteins
• NF-kappaB Transcription Factor Crystallography
• Replication Complex
• DNA Recombination Complexes
• DNA Binding by Alkyltransferase Repair Proteins
• DNA Polymerase Crystallography
• Polymerase Switching in Response to DNA Damage
• Single Molecule Studies on Chromatin
• Regulation of Chromosome Conformation in Cells
• Nucleosome Positioning Across Genomes.