Mitochondrial Dysfunction in Neurodegenerative Disorders

• Corporate Author: SpringerLink (Online service)
• Other Authors: Reeve, Amy Katherine (Editor), Krishnan, Kim Jennifer (Editor), Duchen, Michael R. (Editor), Turnbull, Doug M. (Editor)
• Format: Electronic eBook
• Language: English
• Published: London : Springer London : Imprint: Springer, 2012.
• Subjects: Medicine.; Neurosciences.; Internal medicine.; Medical biochemistry.; Neurology.; Medicine & Public Health.; Medical Biochemistry.; Internal Medicine.

As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such...

Table of Contents:

• An Introduction to Mitochondria
• Neurodegeneration in Primary Mitochondrial Disorders
• Mutations in Nuclear Genes that Affect Mitochondrial Function in Parkinson’s Disease
• Common mtDNA Polymorphisms and Neurodegenerative Disorders
• MtDNA Mutations in Brain Ageing and Neurodegeneration
• Mitochondrial Dysfunction in Neurodegenerative Disease; Protein Aggregation, Autophagy and Oxidative Stress
• Mitochondria, Sodium and Calcium in Neuronal Dysfunction
• Mitochondrial Membrane Potential and Dynamics
• Dysfunction of the Ubiquitin/Proteasome System and Mitochondria in Neurodegenerative Disease
• Neuronal Mitochondrial Transport and Dysfunction
• Mitochondrial Changes Associated With Demyelination: Consequences for Axonal Integrity
• Modelling Mitochondrial Dysfunction in Neurodegenerative Disease
• Could Understanding the Role Of Mitochondria in Neurodegeneration Lead to Treatment?