Proteases and Their Inhibitors in Cancer Metastasis

• Corporate Author: SpringerLink (Online service)
• Other Authors: Foidart, Jean-Michel (Editor), Muschel, Ruth J. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands, 2002.
• Series: Cancer Metastasis — Biology and Treatment, 4
• Subjects: Medicine.; Cancer research.; Oncology.; Biomedicine.; Cancer Research.

In recent years, serine proteases and matrix metalloproteinases (MMPs) have gained considerable attention in tumor biology. For most of these proteases, their expression is a reliable indication of ongoing tissue remodeling. This book provides a comprehensive evaluation of the mechanisms of action o...

Table of Contents:

• Molecular Biology of the Plasminogen System: The Delicate Balance between Tissue Healing and Tissue Destruction
• Role of Serine Proteases and their Inhibitors in Tumor Growth and Angiogenesis
• The Gelatinases, MMP-2 and MMP-9-Implications for Invasion and Metastasis
• The Collagenases: Novel Roles for Matrix Metalloproteinases (MMPS) in Invasion and Metastasis
• Stromelysin-3, a Particular Member of the Matrix Metalloproteinase Family
• Membrane-Type Matrix Metalloproteinases
• 3D Structure and Drug Design
• Transcriptional Control of Proteases
• Tissue Inhibitors of Metalloproteinases in Cancer
• Clinical Aspects of Matrix Metalloproteinases
• Tissue Models to Study Tumor-Stroma Interactions
• Mammalian Heparanase: Molecular Properties, Inhibition and Involvement in Tumor Metastasis and Angiogenesis.