Genome Instability in Cancer Development

• Corporate Author: SpringerLink (Online service)
• Other Authors: Back, Nathan (Editor), Cohen, Irun R. (Editor), Kritchevsky, David (Editor), Lajtha, Abel (Editor), Paoletti, Rodolfo (Editor), Nigg, Erich A. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands, 2005.
• Series: Advances in Experimental Medicine and Biology, 570
• Subjects: Medicine.; Cancer research.; Oncology.; Pathology.; Life sciences.; Cell biology.; Biomedicine.; Cancer Research.; Cell Biology.; Biomedicine general.; Life Sciences, general.

Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinog...