Genome Instability in Cancer Development

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Back, Nathan (Επιμελητής έκδοσης), Cohen, Irun R. (Επιμελητής έκδοσης), Kritchevsky, David (Επιμελητής έκδοσης), Lajtha, Abel (Επιμελητής έκδοσης), Paoletti, Rodolfo (Επιμελητής έκδοσης), Nigg, Erich A. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht : Springer Netherlands, 2005.
• Σειρά: Advances in Experimental Medicine and Biology, 570
• Θέματα: Medicine.; Cancer research.; Oncology.; Pathology.; Life sciences.; Cell biology.; Biomedicine.; Cancer Research.; Cell Biology.; Biomedicine general.; Life Sciences, general.

Research over the past decades has firmly established the genetic basis of cancer. In particular, studies on animal tumour viruses and chromosome rearrangements in human tumours have concurred to identify so-called ‘proto-oncogenes’ and ‘tumour suppressor genes’, whose deregulation promotes carcinog...

Πίνακας περιεχομένων:

• The Multiplicity of Mutations in Human Cancers
• Monitoring Chromosome Rearrangements
• Nucleotide Excision Repair and its Connection with Cancer and Ageing
• DNA Mismatch Repair and Colon Cancer
• Base Excision Repair
• Genomic Instability in Cancer Development
• Translesion Synthesis And Errorprone Polymerases
• The INK4A/Arf Network — Cell Cycle Checkpoint or Emergency Brake?
• DNA Replication and Genomic Instability
• The Dream of Every Chromosome: Equal Segregation for a Healthy Life of the Host
• Telomere Structural Dynamics in Genome Integrity Control and Carcinogenesis
• Gene Amplification Mechanisms
• DNA Methylation and Cancer-associated Genetic Instability
• Deregulation of the Centrosome Cycle and the Origin of Chromosomal Instability in Cancer
• Mammalian DNA Damage Response Pathway
• ATM and Cellular Response to DNA Damage
• Mitotic Checkpoint, Aneuploidy and Cancer.