Drug Metabolism Current Concepts /

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Ionescu, Corina (Επιμελητής έκδοσης), Caira, Mino R. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht : Springer Netherlands, 2005.
• Θέματα: Medicine.; Pharmacy.; Molecular biology.; Pharmacology.; Medicinal chemistry.; Biomedicine.; Biomedicine general.; Medicinal Chemistry.; Pharmacology/Toxicology.; Molecular Medicine.

Drug Metabolism: Current Concepts Corina Ionescu and Mino R Caira Drug Metabolism: Current Concepts provides a comprehensive understanding of the processes that take place following ingestion of a medicinal agent or xenobiotic, with an emphasis on the crucial role of metabolism (biotransformation)....

Πίνακας περιεχομένων:

• Drug Metabolism In Context: Introduction
• Absorption
• Drug Distribution
• Dynamics Of Drug Action
• Drug Clearance
• Dynamics Of Drug Clearance
• Pathways Of Biotransformation – Phase I Reactions: Introduction
• Phase I And Phase Ii Metabolism: General Considerations
• Oxidations Involving The Microsomal Mixed-Function Oxidase System
• Oxidations Involving Other Enzymatic Systems
• Metabolic Reactions Involving Reduction
• Hydrolysis
• Miscellanous Phase I Reactions
• The Fate Of Phase I Reaction Products
• . Pathways Of Biotransformation – Phase I Reactions: Introduction
• Glucuronidation
• Acetylation
• Glutathione Conjugation
• Other Conjugative Reactions
• Concluding Remarks
• Enzymatic Systems Involved In Drug Biotransformation: Ntroduction
• Interaction Between A Drug Substrate And An Enzyme
• Enzyme Systems With Specific Roles
• Final Remarks
• Induction And Inhibition Of Drug-Metabolising Enzymes
• Introduction
• Induction
• Inhibition
• Consequences Of The Above Phenomena
• Dietary And Non-Dietary Factors In Enzyme Induction And Inhibition
• Factors That Influence Drug Biotransformation
• Introduction
• Intrinsic Factors
• Environmental Factors
• Further Observations
• Impact Of Gene Variability On Drug Metabolism
• Introduction
• Basic Principles Of Pharmacogenetics
• Pharmaco-Informatics
• Implications For Third Millennium Medicine
• Drug Interactions And Adverse Reactions: Introduction
• Drug-Drug Interactions
• Interactions Between Drugs And Other Entities
• Adverse Reactions
• Summary
• Strategies For Drug Design
• Introduction
• Pharmacokinetics And Metabolism In Drug Research
• The Role Of Formulation
• Concluding Remarks
• Index.