Structure-Based Drug Discovery

• Main Authors: Jhoti, Harren (Author), Leach, Andrew R. (Author)
• Corporate Author: SpringerLink (Online service)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands, 2007.
• Subjects: Chemistry.; Pharmacy.; Pharmacology.; Physical chemistry.; Medicinal chemistry.; Biochemistry.; Medicinal Chemistry.; Biomedicine general.; Pharmacology/Toxicology.; Biochemistry, general.; Physical Chemistry.

Discovering new medicines is becoming more challenging and the pharmaceutical industry is looking to new technologies to help in this mission. Structure-based drug discovery methods have been transformed in the last 5-10 years and are now having a major impact on the discovery of new drugs. Some of...

Table of Contents:

• Five Years of Increasing Structural Biology Throughput - A Retrospective Analysis
• Protein Production for Structural Genomics - Strategies for the Next Phase
• to Fragment Screening
• Fragment-Based NMR Screening in Lead Discovery
• Fragment-Based Screening by X-ray Crystallography
• Scaffold-Based Drug Discovery
• Biophysical Methods
• Illustration of Current Challenges in Molecular Docking
• Scoring Functions.