RAS Family GTPases

• Corporate Author: SpringerLink (Online service)
• Other Authors: Der, Channing (Editor)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands : Imprint: Springer, 2006.
• Series: Proteins and Cell Regulation ; 4
• Subjects: Medicine.; Cancer research.; Human physiology.; Molecular biology.; Pharmacology.; Cell biology.; Biomedicine.; Cancer Research.; Human Physiology.; Molecular Medicine.; Pharmacology/Toxicology.; Cell Biology.

Since 1982, Ras proteins have been the subject of intense research investigation by the biomedical research community. The wide interest in Ras has been stimulated for three key reasons. First, their frequent mutational activation in human cancers establishes Ras proteins as important mediators of o...

Table of Contents:

• Ras Stories: The State of the Art
• Ras-Gefs and Ras Gaps
• Structural Principles of Ras Interaction with Regulators and Effectors
• RAS and the RAF/MEK/ERK Cascade
• Noncanonical Effector Targets Of Oncogenic Ras Proteins
• Effectors of Ras-Mediated Oncogenesis
• RHO Proteins in RAS Signaling and Transformation
• Global Effects of Ras Signaling on the Genetic Program in Mammalian Cells
• Ras Signaling in C. Elegans
• Ras Family G-Proteins in Saccharomyces Cerevisiae and Schizosaccharomyces Pombe
• Comparison of the Effects of Ras Effector Mutants and Ras Effectors on Transformed and Tumorigenic Growth of Human and Rodent Cells
• Genetically Engineered Mice Harboring RAS Mutations as Models of Human Cancer: in Medias RAS
• Ras Family Proteins
• #x003BA;B-RAS: A Small Gtpase That Influences NF-#x003BA;B Signaling
• Anti-Ras Strategies for Cancer Treatment.