Evolving Methods for Macromolecular Crystallography The Structural Path to the Understanding of the Mechanismof Action of CBRN Agents /

• Corporate Author: SpringerLink (Online service)
• Other Authors: Read, Randy J. (Editor), Sussman, Joel L. (Editor)
• Format: Electronic eBook
• Language: English
• Published: Dordrecht : Springer Netherlands, 2007.
• Series: NATO Science Series, 245
• Subjects: Physics.; Bioinformatics.; Computational biology.; Crystallography.; Biophysics.; Biological physics.; Biophysics and Biological Physics.; Computer Appl. in Life Sciences.

This volume comprises papers presented at the 2005 edition of the “Crystallography of Molecular Biology” courses that have been held since 1976 at the Ettore Majorana Centre for Scientific Culture in Erice, Italy. This series of courses is renowned for bringing leaders in the field of macromo- cular...

Table of Contents:

• Succeeding with seeding: some practical advice
• Expression, purification, and crystallisationof membrane proteins
• Macromolecular cryo-crystallography
• Processing diffraction data with mosflm
• Sad phasing: basic concepts and high-throughput
• Likelihood-based experimental phasing in phaser
• Stochastic molecular replacement
• Likelihood-based molecular replacement in phaser
• Automated structure determination with phenix
• Density Modification In Main
• Ab initio phasing starting from low resolution
• Structural genomics of mycobacterium tuberculosis: a search for function and new drug targets
• Three-dimensional domain swapping and its relevance to conformational diseases
• Structural bioinformatics: from protein structure to function
• Single-particle imaging.