Statistics Applied to Clinical Trials

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Cleophas, Ton J. (Επιμελητής έκδοσης), Zwinderman, Aeilko H. (Επιμελητής έκδοσης), Cleophas, Toine F. (Επιμελητής έκδοσης), Cleophas, Eugene P. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Dordrecht : Springer Netherlands, 2009.
• Θέματα: Mathematics.; Probabilities.; Statistics.; Probability Theory and Stochastic Processes.; Biomedicine general.; Statistics for Life Sciences, Medicine, Health Sciences.; Statistics, general.

In clinical medicine appropriate statistics has become indispensable to evaluate treatment effects. Randomized controlled trials are currently the only trials that truly provide evidence-based medicine. Evidence based medicine has become crucial to optimal treatment of patients. We can define random...

Πίνακας περιεχομένων:

• Hypotheses, Data, Stratification
• The Analysis Of Efficacy Data
• The Analysis of Safety Data
• Log Likelihood Ratio Tests For Safety Data Analysis
• Equivalence Testing
• Statistical Power And Sample Size
• Interim Analyses
• Controlling The Risk of False Positive Clinical Trials
• Multiple Statistical Inferences
• The Interpretation of The P-Values
• Research Data Closer To Expectation Than Compatible With Random Sampling
• Statistical Tables For Testing Data Closer To Expectation Than Compatible With Random Sampling
• Principles Of Linear Regression
• Subgroup Analysis Using Multiple Linear Regression: Confounding, Interaction, Synergism
• Curvilinear Regression
• Logistic and Cox Regression, Markow Models, Laplace Transformations
• Regression Modeling for Improved Precision
• Post-Hoc Analyses in Clinical Trials, a Case for Logistic Regression Analysis
• Confounding
• Interaction
• Meta-Analysis, Basic Approach
• Meta-Analysis, Review and Update of Methodologies
• Crossover Studies with Continuous Variables
• Crossover Studies with Binary Responses
• Cross-Over Trials Should not be Used to Test Treatments with Different Chemical Class
• Quality-of-Life Assessments in Clinical Trials
• Statistical Analysis of Genetic Data
• Relationship Among Statistical Distributions
• Testing Clinical Trials for Randomness
• Clinical Trials do not Use Random Samples Anymore
• Clinical Data Where Variability is More Important than Averages
• Testing Reproducibility
• Validating Qualitative Diagnostic Tests
• Uncertainty of Qualitative Diagnostic Tests
• Meta-Analysis of Diagnostic Accuracy
• Validating Quantitative Diagnostic Tests
• Summary of Validation Procedures for Diagnostic Tests
• Validating Surrogate Endpoints of Clinical Trials
• Methods for Repeated Measures Analysis
• Advanced Analysis of Variance, Random Effects and Mixed Effects Models
• Monte Carlo Methods
• Physicians’ Daily Life and the Scientific Method
• Clinical Trials: Superiority-Testing
• Trend-Testing
• Odds Ratios and Multiple Regression Models, Why and How to Use Them
• Statistics is no “Bloodless” Algebra
• Bias Due to Conflicts of Interests, Some Guidelines.