Cancer Genome and Tumor Microenvironment
Oncogenes and tumor suppressor genes had been traditionally studied in the context of cell proliferation, differentiation, senescence, and survival, four relatively cell-autonomous processes. Consequently, in the late ‘80s-mid ‘90s, neoplastic growth was described largely as a net imbalance between...
| Συγγραφή απο Οργανισμό/Αρχή: | |
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| Άλλοι συγγραφείς: | |
| Μορφή: | Ηλεκτρονική πηγή Ηλ. βιβλίο |
| Γλώσσα: | English |
| Έκδοση: |
New York, NY :
Springer New York,
2010.
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| Σειρά: | Cancer Genetics
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| Θέματα: | |
| Διαθέσιμο Online: | Full Text via HEAL-Link |
Πίνακας περιεχομένων:
- Opening Remarks
- Hardwiring Tumor Progression
- Breaking Away: Epithelial-Mesenchymal Transition
- PI3K/AKT Pathway and the Epithelial-Mesenchymal Transition
- Loss of Cadherin-Catenin Adhesion System in Invasive Cancer Cells
- Rho GTPases in Regulation of Cancer Cell Motility, Invasion, and Microenvironment
- Merlin/NF2 Tumor Suppressor and Ezrin–Radixin–Moesin (ERM) Proteins in Cancer Development and Progression
- Coming up for Air: Hypoxia and Angiogenesis
- von Hippel-Lindau Tumor Suppressor, Hypoxia-Inducible Factor-1, and Tumor Vascularization
- RAS Oncogenes and Tumor-Vascular Interface
- Myc and Control of Tumor Neovascularization
- p53 and Angiogenesis
- Ink4a Locus: Beyond Cell Cycle
- Gaining New Ground: Metastasis and Stromal Cell Interactions
- Nm23 as a Metastasis Inhibitor
- HGF/c-MET Signaling in Advanced Cancers
- Contribution of ADAMs and ADAMTSs to Tumor Expansion and Metastasis
- Stromal Cells and Tumor Milieu: PDGF et al.
- TGF-? Signaling Alterations in Neoplastic and Stromal Cells
- Getting Attention: Immune Recognition and Inflammation
- Genetic Instability and Chronic Inflammation in Gastrointestinal Cancers
- Immunoglobulin Gene Rearrangements, Oncogenic Translocations, B-Cell Receptor Signaling, and B Lymphomagenesis
- Modulation of Philadelphia Chromosome-Positive Hematological Malignancies by the Bone Marrow Microenvironment
- Putting It All Together
- Melanoma: Mutations in Multiple Pathways at the Tumor-Stroma Interface
- Cooperation and Cancer.
