Cell-Extracellular Matrix Interactions in Cancer

• Corporate Author: SpringerLink (Online service)
• Other Authors: Zent, Roy (Editor), Pozzi, Ambra (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2010.
• Edition: 1.
• Subjects: Medicine.; Cancer research.; Pharmacology.; Cell biology.; Biomedicine.; Cancer Research.; Cell Biology.; Pharmacology/Toxicology.

Cells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apo...

Table of Contents:

• The Extracellular Matrix: An Overview
• Integrin Structure and Function
• Cancer in Context: Importance of the Tumor Microenvironment
• Basement Membrane Collagens and Cancer
• Laminins and Cancer Progression
• Fibronectins and Their Receptors in Cancer
• Vitronectin-Binding Integrins in Cancer
• The Function of SPARC in Tumor Cell Biology: SPARC as a Modulator of Cell–Extracellular Matrix Interaction
• Proteoglycans and Cancer
• Tetraspanins in Cancer
• The Role of Integrin-Linked Kinase in Cancer Development and Progression
• Focal Adhesion Kinase with the Interacting Proteins and Signaling in Cancer.