Cellular Senescence and Tumor Suppression

• Corporate Author: SpringerLink (Online service)
• Other Authors: Adams, Peter D. (Editor), Sedivy, John M. (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2010.
• Subjects: Medicine.; Cancer research.; Human genetics.; Pharmacology.; Biomedicine.; Cancer Research.; Human Genetics.; Pharmacology/Toxicology.

Leonard Hayflick and colleagues coined the term "cellular senescence" to describe the inevitable and irreversible proliferation arrest of primary human cells in culture. Specifically, Hayflick and coworkers reported the phenomenon of replicative senescence in primary human fibroblasts, sho...