Cellular Senescence and Tumor Suppression

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Adams, Peter D. (Επιμελητής έκδοσης), Sedivy, John M. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: New York, NY : Springer New York, 2010.
• Θέματα: Medicine.; Cancer research.; Human genetics.; Pharmacology.; Biomedicine.; Cancer Research.; Human Genetics.; Pharmacology/Toxicology.

Leonard Hayflick and colleagues coined the term "cellular senescence" to describe the inevitable and irreversible proliferation arrest of primary human cells in culture. Specifically, Hayflick and coworkers reported the phenomenon of replicative senescence in primary human fibroblasts, sho...

Πίνακας περιεχομένων:

• Senescence signals
• Telomere Biology and Biochemistry
• Role of RecQ Helicases in Nuclear DNA Repair and Telomere Maintenance
• Oncogene-Induced Senescence (OIS) as a Cellular Response to Oncogenic Stresses
• Stress-Induced Senescence
• The senescent phenotype
• The Secretome of Senescent Cells
• Chromatin Structure in Senescent Cells
• A Comparison of Senescence in Mouse and Human Cells
• The physiological consequences of senescence
• Replicative Senescence as an Intrinsic Tumor-Suppressor Mechanism
• Telomere Dysfunction and Senescence in Stem Cell and Tissues Aging
• Mining Cellular Senescence for Drug Targets.