Ribonuclease P

• Corporate Author: SpringerLink (Online service)
• Other Authors: Liu, Fenyong (Editor), Altman, Sidney (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2010.
• Series: Protein Reviews ; 10
• Subjects: Life sciences.; Proteomics.; Life Sciences.

Ribonuclease P (RNaseP), a ribonucleoprotein, is an essential tRNA processing enzyme found in all living organisms. Since its discovery almost 40 years ago, research on RNase P has led to the discovery of the catalytic properties of RNA, and of the only known, naturally occurring RNA enzymes, RNase...

Table of Contents:

• History of RNase P and Overview of Its Catalytic Activity
• The Evolution of RNase P and Its RNA
• Over a Decade of Bacterial Ribonuclease P Modeling
• Structural Studies of Ribonuclease P
• Folding of Bacterial RNase P RNA
• Kinetic Mechanism of Bacterial RNase P
• Roles of Metal Ions in RNase P Catalysis
• Challenges in RNase P Substrate Recognition: Considering the Biological Context
• Archaeal RNase P: A Mosaic of Its Bacterial and Eukaryal Relatives
• Eukaryote RNase P and RNase MRP
• RNase P from Organelles
• Human RNase P and Transcription
• RNase P as a Drug Target
• Ribonuclease P as a Tool.