Muscle Gene Therapy

• Corporate Author: SpringerLink (Online service)
• Other Authors: Duan, Dongsheng (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2010.
• Subjects: Medicine.; Human genetics.; Immunology.; Virology.; Developmental biology.; Biomedicine.; Human Genetics.; Developmental Biology.

Muscle disease represents an important health threat to the general population. For thousands of years, a cure has been deemed extremely remote, if not impossible, for many relentless muscle diseases such as Duchenne muscular dystrophy. The cloning of muscle disease genes and the prospect of introdu...

Table of Contents:

• Animal Models for Inherited Muscle Diseases
• In Utero Muscle Gene Transfer
• Gene Therapy for the Respiratory Muscles
• Muscular Dystrophy Gene Therapy in Small Animal Models
• Antisense-Mediated Exon Skipping for Duchenne Muscular Dystrophy
• Systemic Treatment of Duchenne Muscular Dystrophy by Antisense Oligomer-Induced Exon Skipping
• RNAi Therapy for Dominant Muscular Dystrophies and Other Myopathies
• Combinatorial Gene Therapy Strategies for Treating Muscular Dystrophies
• Duchenne Cardiomyopathy Gene Therapy
• Systemic Gene Delivery for Muscle Gene Therapy
• Modulating Immune Responses in Muscle Gene Therapy
• Delivering Large Therapeutic Genes for Muscle Gene Therapy
• Muscle as a Metabolic Factory for Gene Therapy
• Muscle as a Target for Genetic Vaccine
• Combining Stem Cells and Exon Skipping Strategy to Treat Muscular Dystrophy
• Gene Therapy Clinical Trials for Muscular Dystrophies.