Developmental Plasticity of Inhibitory Circuitry

• Συγγραφή απο Οργανισμό/Αρχή: SpringerLink (Online service)
• Άλλοι συγγραφείς: Pallas, Sarah L. (Επιμελητής έκδοσης)
• Μορφή: Ηλεκτρονική πηγή Ηλ. βιβλίο
• Γλώσσα: English
• Έκδοση: Boston, MA : Springer US, 2010.
• Θέματα: Medicine.; Neurosciences.; Neurology.; Rehabilitation medicine.; Developmental biology.; Neurobiology.; Biomedicine.; Developmental Biology.; Rehabilitation Medicine.

 Neuroscience has long been focused on understanding neural plasticity in both development and adulthood. However, experimental work in this area has focused almost entirely on plasticity at excitatory synapses. A growing body of evidence suggests that plasticity at inhibitory GABAergic and glycinergic synapses is of critical importance during both development and aging. Only a few investigators have been engaged in research on how inhibitory circuits are formed during development or how they are involved in plasticity of developing sensory and motor circuitry. Developmental Plasticity of Inhibitory Circuitry approaches the subject of inhibitory plasticity from several levels of analysis, from synapses to circuits to systems to clinical, summarizing several possible mechanisms and collecting some of the most fascinating work in this under-studied area. It is meant to provide an overview for basic and clinical researchers and students interested in neural plasticity and to stimulate further research. About the Editor: Dr. Sarah L. Pallas is a Professor of Neuroscience and Biology at Georgia State University. She earned her Ph.D. in Neurobiology and Behavior at Cornell University, under the tutelage of Dr. Barbara Finlay. Her postdoctoral training was received at M.I.T. in the laboratory of Dr. Mriganka Sur. Her research concerns developmental neurobiology and sensory physiology, and in particular the role of sensory experience in the development and plasticity of neural circuits. 

 The Origins and Specification of Cortical Interneurons -- Role of Spontaneous Activity in the Maturation of GABAergic Synapses in Embryonic Spinal Circuits -- Regulation of Inhibitory Synapse Function in the Developing Auditory CNS -- Developmental Plasticity of Inhibitory Receptive Field Properties in the Auditory and Visual Systems -- Postnatal Maturation and Experience-Dependent Plasticity of Inhibitory Circuits in Barrel Cortex -- GABAergic Transmission and Neuronal Network Events During Hippocampal Development -- Endocannabinoids and Inhibitory Synaptic Plasticity in Hippocampus and Cerebellum -- Interneuron Pathophysiologies: Paths to Neurodevelopmental Disorders.