Lipid A in Cancer Therapy

• Corporate Author: SpringerLink (Online service)
• Other Authors: Jeannin, Jean-François (Editor)
• Format: Electronic eBook
• Language: English
• Published: New York, NY : Springer New York, 2010.
• Series: Advances in Experimental Medicine and Biology, 667
• Subjects: Medicine.; Biomedicine.; Biomedicine general.

Cancer remains a major challenge for modern society. Not only does cancer rank among the first three causes of mortality in most population groups but also the therapeutic options available for most tumor types are limited. The existing ones have limited efficacy, lack specificity and their administ...

Table of Contents:

• Introduction: Historical Background
• Structure andSynthesis of Lipid A
• Conformation and Supramolecular Structure of Lipid A
• Interactions between Lipid A and Serum Proteins
• The Lipid A Receptor
• Lipid A Receptor TLR4-Mediated Signaling Pathways
• Lipid A-Induced Responses In Vivo
• Lipid A-Mediated Tolerance and Cancer Therapy
• Lipid A in Cancer Therapies Preclinical Results
• Monophosphoryl Lipid A (MPL) as an Adjuvant for Anti-Cancer Vaccines: Clinical Results
• Antitumoral Effects of Lipids A, Clinical Studies
• Conclusion.